Macrophage silica nanoparticle response is phenotypically dependent.

ABSTRACT: Phagocytes are important players in host exposure to nanomaterials. Macrophages in particular are believed to be among the "first responders" and primary cell types that uptake and process nanoparticles, mediating host biological responses by subsequent interactions with inflammatory signaling pathways and immune cells. However, variations in local microenvironmental cues can significantly change the functional and phenotype of these cells, impacting nanoparticle uptake and overall physiological response. Herein we focus on describing the response of specific RAW 264.7 macrophage phenotypes (M1, INF-gamma/LPS induced and M2, IL-4 induced) to Stöber silica nanoparticle exposure in vitro and how this response might correlate with macrophage response to nanoparticles in vivo. It was observed

SUBMITTER: Herd HL 

PROVIDER: S-EPMC4405667 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature