Circulating miR-200c and miR-141 and outcomes in patients with breast cancer.

ABSTRACT:

Background

The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 in the whole blood can identify breast cancer (BC), and could be developed into a prognostic signature.

Methods

The expression of miR-200c and miR-141 were examined in bloods (57 stage I-IV BC patients and 20 age-matched controls) by quantitative reverse-transcription PCR. The associations of circulating microRNAs with clinic and pathological characteristics were analysed. Their effects on survival were analysed by the Kaplan-Meier method and Cox regressions.

Results

MiR-200c was down regulated (P < 0.0001) in the blood of BC patients, yielded an area under t

SUBMITTER: Antolin S 

PROVIDER: S-EPMC4405843 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature