Evaluation of a Method for Estimating Retinal Ganglion Cell Counts Using Visual Fields and Optical Coherence Tomography.

ABSTRACT:

Purpose

To evaluate the accuracy and generalizability of a published model that derives estimates of retinal ganglion cell (RGC) counts and relates structural and functional changes due to glaucoma.

Methods

Both the Harwerth et al. nonlinear model (H-NLM) and the Hood and Kardon linear model (HK-LM) were applied to an independent dataset of frequency-domain optical coherence tomography and visual fields, consisting of 48 eyes of 48 healthy controls, 100 eyes of 77 glaucoma patients and suspects, and 18 eyes of 14 nonarteritic anterior ischemic optic neuropathy (ION) patients with severe vision loss. Using the coefficient of determination R2, the models were compared while keeping constant the topographic maps, specifically a map by Garway-Heath et al. and a separate map by H

SUBMITTER: Raza AS 

PROVIDER: S-EPMC4406034 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature