MicroRNA-mediated regulation of p21 and TASK1 cellular restriction factors enhances HIV-1 infection.

ABSTRACT: MicroRNAs (miRNAs) are short non-coding RNAs that play a central role in the regulation of gene expression by binding to target mRNAs. Several studies have revealed alterations in cellular miRNA profiles following HIV-1 infection, mostly for miRNAs involved in inhibiting viral infection. These miRNA expression modifications might also serve to block the innate HIV-1 inhibition mechanism. As a result, it is expected that during HIV-1 infection miRNAs target genes that hinder or prevent the progression of the HIV-1 replication cycle. One of the major sets of genes known to inhibit the progression of HIV-1 infection are cellular restriction factors. In this study, we identified a direct miRNA target gene that modulates viral spread in T-lymphocytes and HeLa-CCR5 cell lines. Following infectio

SUBMITTER: Farberov L 

PROVIDER: S-EPMC4406127 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature