Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome.

ABSTRACT:

Purpose/aim

Acute Respiratory Distress Syndrome (ARDS) is an important clinical and public health problem. Why some at-risk individuals develop ARDS and others do not is unclear but may be related to differences in inflammatory and cell signaling systems. The Receptor for Advanced Glycation Endproducts (RAGE) and Granulocyte-Monocyte Stimulating Factor (GM-CSF) pathways have recently been implicated in pulmonary pathophysiology; whether genetic variation within these pathways contributes to ARDS risk or outcome is unknown.

Materials and methods

We studied 842 patients from three centers in Utah and 14 non-Utah ARDS Network centers. We studied patients at risk for ARDS and patients with ARDS to determine whether Single Nucleotide Polymorphisms (SNPs) in the RAGE and GM-CSF pa

SUBMITTER: Brown SM 

PROVIDER: S-EPMC4406221 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature