Apolipoprotein E genotype and cognitive function in postmenopausal women with early-stage breast cancer.

ABSTRACT:

Purpose/objectives

To examine the role of apolipoprotein E (APOE) genotype in the cognitive function of postmenopausal women with early-stage breast cancer prior to initiation of adjuvant therapy and over time with treatment.

Design

Longitudinal, genetic association study.

Setting

Urban university cancer center.

Sample

Three cohorts of postmenopausal women: 37 women with breast cancer receiving chemotherapy and anastrozole, 41 women with breast cancer receiving anastrozole alone, and 50 healthy women.

Methods

Cognitive function was evaluated three times during a 12-month period using a comprehensive neuropsychological test battery. Participants were genotyped and classified based on the presence or absence of at least one APOE e4 allele. Multiple linear

SUBMITTER: Koleck TA 

PROVIDER: S-EPMC4406250 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature