Ontology highlight
ABSTRACT:
SUBMITTER: Niso-Santano M
PROVIDER: S-EPMC4406650 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
The EMBO journal 20150113 8
To obtain mechanistic insights into the cross talk between lipolysis and autophagy, two key metabolic responses to starvation, we screened the autophagy-inducing potential of a panel of fatty acids in human cancer cells. Both saturated and unsaturated fatty acids such as palmitate and oleate, respectively, triggered autophagy, but the underlying molecular mechanisms differed. Oleate, but not palmitate, stimulated an autophagic response that required an intact Golgi apparatus. Conversely, autopha ...[more]