In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes.

ABSTRACT: Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of caloric restriction, the most effective rejuvenating treatment known so far. Analysis of the transcriptomic profiles of SAMP8 astrocytes cultured in control conditions and treated with caloric restriction serum was performed using mRNA microarrays. A decrease in mitochondrial and ribosome mRNA, which was restored by caloric restriction, confirmed the age-related profile of SAMP8 astrocytes and the benefits of caloric restriction. An amelioration of antioxidant and neurodegenerati

SUBMITTER: Garcia-Matas S 

PROVIDER: S-EPMC4406662 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature