FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway.

ABSTRACT: Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study, the receptor of follicle-stimulating hormone (FSH), a gonadotropin that increases sharply and persistently with aging in both males and females, is functionally expressed in human and mouse fat tissues and adipocytes. Follicle-stimulating hormone was found to promote lipid biosynthesis and lipid droplet formation; FSH could also alter the secretion of leptin and adiponectin, but not hyperplasia, in vitro and in vivo. The effects of FSH are mediated by FSH receptors coupled to the Gαi protein; as

SUBMITTER: Liu XM 

PROVIDER: S-EPMC4406670 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature