Re-replication of a centromere induces chromosomal instability and aneuploidy.

ABSTRACT: The faithful inheritance of chromosomes during cell division requires their precise replication and segregation. Numerous mechanisms ensure that each of these fundamental cell cycle events is performed with a high degree of fidelity. The fidelity of chromosomal replication is maintained in part by re-replication controls that ensure there are no more than two copies of every genomic segment to distribute to the two daughter cells. This control is enforced by inhibiting replication initiation proteins from reinitiating replication origins within a single cell cycle. Here we show in Saccharomyces cerevisiae that re-replication control is important for the fidelity of chromosome segregation. In particular, we demonstrate that transient re-replication of centromeric DNA due to disruption of re

SUBMITTER: Hanlon SL 

PROVIDER: S-EPMC4406714 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature