Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis.

ABSTRACT:

Objective

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently affecting patients with synucleinopathies, but its exact prevalence in multiple system atrophy (MSA) is unclear. Whether questionnaires alone are sufficient to diagnose RBD is also unknown.

Methods

We performed a cross-sectional study of patients with probable MSA from six academic centers in the US and Europe. RBD was ascertained clinically and with polysomnography; we also performed a meta-analysis according to PRISMA guidelines for studies published before September 2014 that reported the prevalence of RBD in MSA. A random-effects model was constructed using weighted prevalence proportions. Only articles in English were included. Studies were classified into those that ascertained

SUBMITTER: Palma JA 

PROVIDER: S-EPMC4406814 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature