Spectrum of aortic valve abnormalities associated with aortic dilation across age groups in Turner syndrome.

ABSTRACT:

Background

Congenital aortic valve fusion is associated with aortic dilation, aneurysm, and rupture in girls and women with Turner syndrome. Our objective was to characterize aortic valve structure in subjects with Turner syndrome and to determine the prevalence of aortic dilation and valve dysfunction associated with different types of aortic valves.

Methods and results

The aortic valve and thoracic aorta were characterized by cardiovascular MRI in 208 subjects with Turner syndrome in an institutional review board-approved natural history study. Echocardiography was used to measure peak velocities across the aortic valve and the degree of aortic regurgitation. Four distinct valve morphologies were identified: tricuspid aortic valve, 64% (n=133); partially fused aortic valve

SUBMITTER: Olivieri LJ 

PROVIDER: S-EPMC4407276 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature