Divergent, coexisting Pseudomonas aeruginosa lineages in chronic cystic fibrosis lung infections.

ABSTRACT:

Rationale

Pseudomonas aeruginosa, the predominant cause of chronic airway infections of patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within and between sputum samples, but little is known about the underlying genetic diversity.

Objectives

To characterize the population genetic structure of transmissible P. aeruginosa Liverpool Epidemic Strain in chronic infections of nine patients with cystic fibrosis, and infer evolutionary processes associated with adaptation to the cystic fibrosis lung.

Methods

We performed whole-genome sequencing of P. aeruginosa isolates and pooled populations and used comparative analyses of genome sequences including phylogenetic reconstructions and resolution of population structure from genome-wide all

SUBMITTER: Williams D 

PROVIDER: S-EPMC4407486 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature