Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling.

ABSTRACT: Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in the development of microphysiological systems for drug development studies. Determination of the proper design principles and scaling rules for body-on-a-chip systems is critical for their strategic incorporation into physiologically based pharmacokinetic (PBPK)/pharmacodynamic (PD) model-aided drug development. While the need for a functional design considering organ-organ interactions has been considered, robust design criteria and steps to build such systems have not yet been defined mathematically. In this paper, we first discuss strategies for incorporating body-on-a-chip technology into the current PBPK modeling-based drug discovery to provide a conceptual model. We propose two t

SUBMITTER: Abaci HE 

PROVIDER: S-EPMC4407827 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature