Ontology highlight
ABSTRACT:
SUBMITTER: Cui H
PROVIDER: S-EPMC4407828 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature communications 20150413
Tat-interactive protein 60 (Tip60) is a MYST histone acetyltransferase that catalyses acetylation of the major DNA damage kinase Ataxia telangiectasia mutated (ATM), thereby triggering cellular signalling required for the maintenance of genomic stability on genotoxic insults. The Tip60 activity is modulated by post-translational modifications that alter its stability and its interactions with substrates. Here we report that activating transcription factor 3 (ATF3), a common stress mediator and a ...[more]