HoxA and HoxD expression in a variety of vertebrate body plan features reveals an ancient origin for the distal Hox program.

ABSTRACT:

Background

Hox genes are master regulatory genes that specify positional identities during axial development in animals. Discoveries regarding their concerted expression patterns have commanded intense interest due to their complex regulation and specification of body plan features in jawed vertebrates. For example, the posterior HoxD genes switch to an inverted collinear expression pattern in the mouse autopod where HoxD13 switches from a more restricted to a less restricted domain relative to its neighboring gene on the cluster. We refer to this program as the 'distal phase' (DP) expression pattern because it occurs in distal regions of paired fins and limbs, and is regulated independently by elements in the 5' region upstream of the HoxD cluster. However, few taxa have been eval

SUBMITTER: Archambeault S 

PROVIDER: S-EPMC4407844 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature