Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome.

ABSTRACT:

Background

In this case-control study we investigated the relative contribution of commons APOA5 polymorphisms and haplotypes to the risk of metabolic syndrome in Moroccan patients.

Methods

Using the International Diabetes Federation (IDF) criteria for metabolic syndrome, the study included 176 patients and 105 controls. We genotyped APOA5 polymorphisms (-1131 T > C, c.56C > G, c.553G > T and c.1259 T > C) by PCR-RFLP analysis. The effects of APOA5 polymorphisms and constructed haplotypes on metabolic syndrome were estimated using logistic regression analyses.

Results

The statistical analysis showed a significant association between APOA5 -1131 T > C and APOA5 c.56C > G polymorphisms with metabolic syndrome in both Codominant and Dominant models. The APOA5 -1131 T > C

SUBMITTER: Ajjemami M 

PROVIDER: S-EPMC4407873 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature