Differential gene expression in liver tissues of streptozotocin-induced diabetic rats in response to resveratrol treatment.

ABSTRACT: This study was conducted to elucidate the genome-wide gene expression profile in streptozotocin induced diabetic rat liver tissues in response to resveratrol treatment and to establish differentially expressed transcription regulation networks with microarray technology. In addition to measure the expression levels of several antioxidant and detoxification genes, real-time quantitative polymerase chain reaction (qRT-PCR) was also used to verify the microarray results. Moreover, gene and protein expressions as well as enzymatic activities of main antioxidant enzymes; superoxide dismutase (SOD-1 and SOD-2) and glutathione S-transferase (GST-Mu) were analyzed. Diabetes altered 273 genes significantly and 90 of which were categorized functionally which suggested that genes in cellular catalyti

SUBMITTER: Sadi G 

PROVIDER: S-EPMC4408020 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature