Patients with systemic lupus erythematosus have higher prevalence of thyroid autoantibodies: a systematic review and meta-analysis.

ABSTRACT:

Background

Thyroid autoimmunity is considered the most common type of organ-specific autoimmune disorder and can be associated with other autoimmune endocrine disorders or non-endocrine diseases. Systemic lupus erythematosus is a prototypical autoimmune disorder with multifactorial etiology. The pathogenesis and development of the disease may result from a loss of immune tolerance and the resulting synthesis of autoantibodies against nuclear antigens. Autoimmune factors may be common features of both thyroid autoimmunity and systemic lupus erythematosus, making it likely that both conditions may coexist within some patients.

Methods and findings

A number of studies have investigated whether an association between thyroid autoimmunity and systemic lupus erythematosus exists.

SUBMITTER: Pan XF 

PROVIDER: S-EPMC4408090 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature