Responses in gut microbiota and fat metabolism to a halogenated methane analogue in Sprague Dawley rats.

ABSTRACT: Recent studies on germ-free mice show that intestinal methanogens may be closely associated with host's adipose metabolism. The present study aimed to investigate effects of inhibition of intestinal methanogen populations on host fat metabolism by establishing a healthy Sprague Dawley (SD) rat model through the intragastric administration of bromochlordomethane (BCM). Forty-five 8-week old healthy male SD rats were randomly divided into five groups including one control and four BCM treatments. The experiment lasted 60 days with two separate 30-day experimental periods. At the end of first period, three BCM treatment groups were further used: one group continued with BCM treatment, one group stopped with BCM treatment, and the other one inoculated with faecal mixture of methanogens from ra

SUBMITTER: Su Y 

PROVIDER: S-EPMC4408184 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature