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Medulloblastoma development: tumor biology informs treatment decisions.

ABSTRACT: Medulloblastoma is the most common malignant pediatric brain tumor. Current treatments including surgery, craniospinal radiation and high-dose chemotherapy have led to improvement in survival. However, the risk for recurrence as well as significant long-term neurocognitive and endocrine sequelae associated with current treatment modalities underscore the urgent need for novel tumor-specific, normal brain-sparing therapies. It has also provided the impetus for research focused on providing a better understanding of medulloblastoma biology. The expectation is that such studies will lead to the identification of new therapeutic targets and eventually to an increase in personalized treatment approaches.

SUBMITTER: Gopalakrishnan V

PROVIDER: S-EPMC4408195 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Medulloblastoma development: tumor biology informs treatment decisions.

Gopalakrishnan Vidya V Tao Rong-Hua RH Dobson Tara T Brugmann William W Khatua Soumen S

CNS oncology 20150101 2

Medulloblastoma is the most common malignant pediatric brain tumor. Current treatments including surgery, craniospinal radiation and high-dose chemotherapy have led to improvement in survival. However, the risk for recurrence as well as significant long-term neurocognitive and endocrine sequelae associated with current treatment modalities underscore the urgent need for novel tumor-specific, normal brain-sparing therapies. It has also provided the impetus for research focused on providing a bett ...[more]

PMID: 25768332

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