Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population.

ABSTRACT:

Objective

To identify novel genetic markers of obesity-related traits and to identify gene-diet interactions with n-3 polyunsaturated fatty acid (n-3 PUFA) intake in Yup'ik people.

Material and methods

We measured body composition, plasma adipokines and ghrelin in 982 participants enrolled in the Center for Alaska Native Health Research (CANHR) Study. We conducted a genome-wide SNP linkage scan and targeted association analysis, fitting additional models to investigate putative gene-diet interactions. Finally, we performed bioinformatic analysis to uncover likely candidate genes within the identified linkage peaks.

Results

We observed evidence of linkage for all obesity-related traits, replicating previous results and identifying novel regions of interest for adiponec

SUBMITTER: Vaughan LK 

PROVIDER: S-EPMC4408244 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature