Memory fMRI predicts verbal memory decline after anterior temporal lobe resection.

ABSTRACT:

Objective

To develop a clinically applicable memory functional MRI (fMRI) method of predicting postsurgical memory outcome in individual patients.

Methods

In this prospective cohort study, 50 patients with temporal lobe epilepsy (23 left) and 26 controls underwent an fMRI memory encoding paradigm of words with a subsequent out-of-scanner recognition assessment. Neuropsychological assessment was performed preoperatively and 4 months after anterior temporal lobe resection, and at equal time intervals in controls. An event-related analysis was used to explore brain activations for words remembered and change in verbal memory scores 4 months after surgery was correlated with preoperative activations. Individual lateralization indices were calculated within a medial temporal and

SUBMITTER: Sidhu MK 

PROVIDER: S-EPMC4408284 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature