The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts.

ABSTRACT:

Unlabelled

P2045 is a peptide analog of somatostatin with picomolar affinity for the somatostatin receptor subtype 2 (SSTR2) upregulated in some pancreatic tumors. Studies were conducted in rat AR42J pancreatic tumor xenograft mice to determine whether (188)Re-P2045 could inhibit the growth of pancreatic cancer in an animal model.

Methods

(188)Re-P2045 was intravenously administered every 3 d for 16 d to nude mice with AR42J tumor xenografts that were approximately 20 mm(3) at study initiation. Tumor volumes were recorded throughout the dosing period. At necropsy, all tissues were assessed for levels of radioactivity and evaluated for histologic abnormalities. Clinical chemistry and hematology parameters were determined from terminal blood samples. The affinity of nonradioac

SUBMITTER: Nelson CA 

PROVIDER: S-EPMC4408534 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature