Transcriptional regulation of autophagy in RAS-driven cancers.

ABSTRACT: RAS-driven cancers exhibit variable dependency on autophagy for survival; however, it is not fully understood how. In this issue of the JCI, Cheong and colleagues demonstrate that RAS-dependent elevation of casein kinase 1α (CK1α) negatively regulates autophagy at the level of autophagy gene transcription. Moreover, combined inhibition of both CK1α and autophagy reduced proliferation of RAS-driven tumors. The results of this study provide insight into the connection between mutant RAS and autophagy, and suggest targeting CK1α as a potential therapeutic strategy to modulate autophagy in RAS-driven cancers.

SUBMITTER: Amaravadi RK 

PROVIDER: S-EPMC4409024 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature