Gene expression analysis of E. coli strains provides insights into the role of gene regulation in diversification.

ABSTRACT: Escherichia coli spans a genetic continuum from enteric strains to several phylogenetically distinct, atypical lineages that are rare in humans, but more common in extra-intestinal environments. To investigate the link between gene regulation, phylogeny and diversification in this species, we analyzed global gene expression profiles of four strains representing distinct evolutionary lineages, including a well-studied laboratory strain, a typical commensal (enteric) strain and two environmental strains. RNA-Seq was employed to compare the whole transcriptomes of strains grown under batch, chemostat and starvation conditions. Highly differentially expressed genes showed a significantly lower nucleotide sequence identity compared with other genes, indicating that gene regulation and coding se

SUBMITTER: Vital M 

PROVIDER: S-EPMC4409157 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature