Rapid emergence of multidrug resistant, H58-lineage Salmonella typhi in Blantyre, Malawi.

ABSTRACT:

Introduction

Between 1998 and 2010, S. Typhi was an uncommon cause of bloodstream infection (BSI) in Blantyre, Malawi and it was usually susceptible to first-line antimicrobial therapy. In 2011 an increase in a multidrug resistant (MDR) strain was detected through routine bacteriological surveillance conducted at Queen Elizabeth Central Hospital (QECH).

Methods

Longitudinal trends in culture-confirmed Typhoid admissions at QECH were described between 1998-2014. A retrospective review of patient cases notes was conducted, focusing on clinical presentation, prevalence of HIV and case-fatality. Isolates of S. Typhi were sequenced and the phylogeny of Typhoid in Blantyre was reconstructed and placed in a global context.

Results

Between 1998-2010, there were a mean of 14 m

SUBMITTER: Feasey NA 

PROVIDER: S-EPMC4409211 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature