Ontology highlight
ABSTRACT:
SUBMITTER: Lai KM
PROVIDER: S-EPMC4409293 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150424 4
In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal lethality to defects associated with premature aging and morphological and functional abnormalities in the lungs, skeleton, and muscle. Each mutant allele carried a lacZ reporter whose expression profile highlighted a wide spectrum of spatiotemporal and tissue-specific transcription patterns in embryos an ...[more]