Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium.

ABSTRACT: Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion. It has been proposed that this functional diversity would require a heterogeneous population of raft domains with varying compositions. However, a mechanism for such diversification is not known. We recently discovered that bacterial membranes organize their signal transduction pathways in functional membrane microdomains (FMMs) that are structurally and functionally similar to the eukaryotic lipid rafts. In this report, we took advantage of the tractability of the prokaryotic model Bacillus subtilis to provide evidence for the coexistence of two distinct families o

SUBMITTER: Schneider J 

PROVIDER: S-EPMC4409396 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature