Factors Determining δ-Bilirubin Levels in Infants With Biliary Atresia.

ABSTRACT:

Objectives

δ-Bilirubin (Bδ) forms when bilirubin conjugates covalently bind to albumin by way of nonenzymatic transesterification in patients with cholestasis. Infants with cholestasis with biliary atresia form Bδ. The aim of the present study was to investigate the factors determining serum Bδ concentrations in infants with biliary atresia.

Methods

Study patients were infants enrolled in a prospective study (PROBE: Clinicaltrials.gov NCT00061828) of biliary atresia. We acquired data of concurrently measured serum bilirubin analytes (total bilirubin [TB], conjugated bilirubin [Bc], and unconjugated bilirubin) and applied graphical methods and linear mixed effects model to study factors contributing to Bδ variability.

Results

Bδ level increased with increasing levels o

SUBMITTER: Ye W 

PROVIDER: S-EPMC4409472 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature