A review of sleep deprivation studies evaluating the brain transcriptome.

ABSTRACT: Epidemiological studies show a positive association between adequate sleep and good health. Further, disrupted sleep may increase the risk for CNS diseases, such as stroke and Alzheimer's disease. However, there has been limited progress in determining how sleep is linked to brain health or how sleep disruption may increase susceptibility to brain insult and disease. Animal studies can aid in understanding these links. In reviewing the animal literature related to the effects of sleep disruption on the brain, we found most of the work was directed toward investigating and characterizing the role of various brain areas or structures in initiating and regulating sleep. In contrast, limited effort has been directed towards understanding how sleep disruption alters the brain's health or suscep

SUBMITTER: Elliott AS 

PROVIDER: S-EPMC4409616 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature