Trace element supplementation in hemodialysis patients: a randomized controlled trial.

ABSTRACT:

Background

People with kidney failure are often deficient in zinc and selenium, but little is known about the optimal way to correct such deficiency.

Methods

We did a double-blind randomized trial evaluating the effects of zinc (Zn), selenium (Se) and vitamin E added to the standard oral renal vitamin supplement (B and C vitamins) among hemodialysis patients in Alberta, Canada. We evaluated the effect of two daily doses of the new supplement (medium dose: 50 mg Zn, 75 mcg Se, 250 IU vitamin E; low dose: 25 mg Zn, 50 mcg Se, 250 IU vitamin E) compared to the standard supplement on blood concentrations of Se and Zn at 90 days (primary outcome) and 180 days (secondary outcome) as well as safety outcomes.

Results

We enrolled 150 participants. The proportion of participant

SUBMITTER: Tonelli M 

PROVIDER: S-EPMC4409771 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature