Plaque burden in HIV-infected patients is associated with serum intestinal microbiota-generated trimethylamine.

ABSTRACT:

Objective

Some intestinal microbiota-generated metabolites of phosphatidylcholine are recognized to be proatherogenic. As the HIV population is vulnerable to cardiovascular disease and can develop intestinal dysbiosis associated with systemic inflammation, we investigated the novel relationship between microbiota-derived metabolites of phosphatidylcholine and coronary atherosclerosis in HIV.

Design/methods

One hundred and fifty-five HIV-infected and 67 non-HIV-infected individuals without known history of cardiovascular disease were previously recruited to assess coronary plaque by computed tomography angiography. In the current study, we evaluate whether serum choline, trimethylamine (TMA), or trimethylamine-N-oxide (TMAO) levels are associated with plaque features.

Resu

SUBMITTER: Srinivasa S 

PROVIDER: S-EPMC4410017 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature