MRNA expression of VEGF and its receptors in fallopian tubes of women with ectopic pregnancies.

ABSTRACT:

Background

Establishment of viable pregnancy requires embryo implantation and placentation. Ectopic pregnancy (EP) is a pregnancy complication which occurs when an embryo implants outside of the uterine cavity, most often in a fallopian tube. On the other hand, an important aspect of successful implantation is angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor responsible for vascular development that acts through its receptors, VEGF receptor 1 (VEGFR1) and VEGFR2. This study aims to investigate mRNA expression of VEGF and its receptors in fallopian tubes of women who have EP compared with fallopian tubes of pseudo-pregnant women. We hypothesize that expression of VEGF and its receptors in human fallopian tubes may change during EP.

Materials a

SUBMITTER: Zarezade N 

PROVIDER: S-EPMC4410038 | biostudies-literature | 2015 Apr-Jun

REPOSITORIES: biostudies-literature