Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.

ABSTRACT:

Context

Although family studies have shown that male lower urinary tract symptoms (LUTS) are highly heritable, no systematic review exists of genetic polymorphisms tested for association with LUTS.

Objective

To systematically review and meta-analyze studies assessing candidate polymorphisms/genes tested for an association with LUTS, and to assess the strength, consistency, and potential for bias among pooled associations.

Evidence acquisition

A systematic search of the PubMed and HuGE databases as well as abstracts of major urologic meetings was performed through to January 2013. Case-control studies reporting genetic associations in men with LUTS were included. Reviewers independently and in duplicate screened titles, abstracts, and full texts to determine eligibilit

SUBMITTER: Cartwright R 

PROVIDER: S-EPMC4410299 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature