Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers.

ABSTRACT:

Background

Candidate biomarkers have been identified for clear cell renal cell carcinoma (ccRCC) patients, but most have not been validated.

Objective

To validate published ccRCC prognostic biomarkers in an independent patient cohort and to assess intratumour heterogeneity (ITH) of the most promising markers to guide biomarker optimisation.

Design, setting, and participants

Cancer-specific survival (CSS) for each of 28 identified genetic or transcriptomic biomarkers was assessed in 350 ccRCC patients. ITH was interrogated in a multiregion biopsy data set of 10 ccRCCs.

Outcome measurements and statistical analysis

Biomarker association with CSS was analysed by univariate and multivariate analyses.

Results and limitations

A total of 17 of 28 biomarkers (TP

SUBMITTER: Gulati S 

PROVIDER: S-EPMC4410302 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature