White matter microstructure in schizophrenia: associations to neurocognition and clinical symptomatology.

ABSTRACT:

Background

Diffusion tensor imaging (DTI) studies in schizophrenia report widespread aberrations in brain white matter (WM). These appear related to poorer neurocognitive performance and higher levels of negative and positive symptomatology. However, identification of the most salient WM aberrations to neurocognition and clinical symptoms is limited by relatively small samples with divergent results.

Methods

We examined 53 well-characterized patients with schizophrenia and 62 healthy controls. All participants were administered a computerized neurocognitive battery, which evaluated performance in several domains. Patients were assessed for negative and positive symptoms. Fractional anisotropy (FA) of WM cortical regions and WM fiber tracts were compared across the groups. FA

SUBMITTER: Roalf DR 

PROVIDER: S-EPMC4410368 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature