Association of adiponectin gene polymorphism with adiponectin levels and risk for insulin resistance syndrome.

ABSTRACT:

Background

Adiponectin is an abundant adipose tissue-derived protein with anti-atherogenic, anti-inflammatory and antidiabetic properties. Plasma adiponectin levels are decreased in obesity, type 2 diabetes, and coronary artery disease and low adiponectin levels also predict insulin resistance (IR).

Methods

Case-control study in which 642 male and female subjects were participated from the North Indian population. Lipid, insulin, leptin and adiponectin level were estimated using standard protocols by commercially available test kits. Single nucleotide polymorphisms +45T>G and +276G>T of the AMP1 (adiponectin) gene was genotyped by polymerase chain reaction restriction fragment length polymorphism method.

Results

Levels of adiponectin, insulin, homeostasis model assess

SUBMITTER: Prakash J 

PROVIDER: S-EPMC4410438 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature