Identifiable biomarker and treatment development using HIV-1 long term non-progressor sera.

ABSTRACT:

Background

HIV-infected long-term non-progressor (LTNP) subjects can prevent viral replication and may harbor useful information for the development of both antibody and active vaccination treatments. In this study we used LTNP sera to examine the epitopes presented to the gp160 protein, and from this procedure we hope to elucidate potential biomarkers pertaining to the level of resistance a patient may have in developing AIDS after infection with HIV. We used five clinical sera samples from LTNP patients to identify common epitopes by ELISA; peptides with high binding to sera were selected and analyzed for conservation among HIV clades. Antibodies were generated against one identified epitope using a chimeric peptide in BALB/c mice, and both the sera from these mice and LTNP sera

SUBMITTER: Hao Y 

PROVIDER: S-EPMC4410489 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature