The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens.

ABSTRACT:

Summary

Neglected tropical diseases (NTDs) caused by helminths constitute some of the most common infections of the world's poorest people. The etiological agents are complex and recalcitrant to standard techniques of molecular biology. Drug screening against helminths has often been phenotypic and typically involves manual description of drug effect and efficacy. A key challenge is to develop automated, quantitative approaches to drug screening against helminth diseases. The quantal dose-response calculator (QDREC) constitutes a significant step in this direction. It can be used to automatically determine quantitative dose-response characteristics and half-maximal effective concentration (EC50) values using image-based readouts from phenotypic screens, thereby allowing rigorous co

SUBMITTER: Asarnow D 

PROVIDER: S-EPMC4410654 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature