Empowering biologists with multi-omics data: colorectal cancer as a paradigm.

ABSTRACT:

Motivation

Recent completion of the global proteomic characterization of The Cancer Genome Atlas (TCGA) colorectal cancer (CRC) cohort resulted in the first tumor dataset with complete molecular measurements at DNA, RNA and protein levels. Using CRC as a paradigm, we describe the application of the NetGestalt framework to provide easy access and interpretation of multi-omics data.

Results

The NetGestalt CRC portal includes genomic, epigenomic, transcriptomic, proteomic and clinical data for the TCGA CRC cohort, data from other CRC tumor cohorts and cell lines, and existing knowledge on pathways and networks, giving a total of more than 17 million data points. The portal provides features for data query, upload, visualization and integration. These features can be flexibly co

SUBMITTER: Zhu J 

PROVIDER: S-EPMC4410657 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature