Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis.

ABSTRACT:

Background

Periodontitis is a polymicrobial biofilm-induced inflammatory disease that affects 743 million people worldwide. The current model to explain periodontitis progression proposes that changes in the relative abundance of members of the oral microbiome lead to dysbiosis in the host-microbiome crosstalk and then to inflammation and bone loss. Using combined metagenome/metatranscriptome analysis of the subgingival microbiome in progressing and non-progressing sites, we have characterized the distinct molecular signatures of periodontitis progression.

Methods

Metatranscriptome analysis was conducted on samples from subgingival biofilms from progressing and stable sites from periodontitis patients. Community-wide expression profiles were obtained using Next Generation Se

SUBMITTER: Yost S 

PROVIDER: S-EPMC4410737 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature