Noninvasive ventilation improves sleep in amyotrophic lateral sclerosis: a prospective polysomnographic study.

ABSTRACT:

Study objective

To evaluate the effects of noninvasive ventilation (NIV) on sleep in patients with amyotrophic lateral sclerosis (ALS) after meticulous titration with polysomnography (PSG).

Methods

In this prospective observational study, 24 ALS patients were admitted to the sleep laboratory during 4 nights for in-hospital NIV titration with PSG and nocturnal capnography. Questionnaires were used to assess subjective sleep quality and quality of life (QoL). Patients were readmitted after one month.

Results

In the total group, slow wave sleep and REM sleep increased and the arousal-awakening index improved. The group without bulbar involvement (non-bulbar) showed the same improvements, together with an increase in sleep efficiency. Nocturnal oxygen and carbon dioxide l

SUBMITTER: Vrijsen B 

PROVIDER: S-EPMC4410930 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature