Emerging β-amyloid pathology and accelerated cortical atrophy.

ABSTRACT:

Importance

The effect of β-amyloid (Aβ) accumulation on regional structural brain changes in early stages of Alzheimer disease (AD) is not well understood.

Objective

To test the hypothesis that the development of Aβ pathology is related to increased regional atrophy in the brains of cognitively normal (CN) persons.

Design, setting, and participants

Longitudinal clinicobiomarker cohort study involving 47 CN control subjects and 15 patients with AD dementia. All participants underwent repeated cerebrospinal fluid Aβ42 and structural magnetic resonance imaging measurements for up to 4 years. Cognitively normal controls were classified using the longitudinal cerebrospinal fluid Aβ42 data and included 13 stable Aβ negative (normal baseline Aβ42 levels, with less than the m

SUBMITTER: Mattsson N 

PROVIDER: S-EPMC4410966 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature