Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism.

ABSTRACT: Delivering therapeutic cargos to specific cell types in vivo poses many technical challenges. There is currently a plethora of drug leads and therapies against numerous diseases, ranging from small molecule compounds to nucleic acids to peptides to proteins with varying binding or enzymatic functions. Many of these candidate therapies have documented potential for mitigating or reversing disease symptoms, if only a means for gaining access to the intracellular target were available. Recent advances in our understanding of the biology of cellular uptake and transport processes and the mode of action of bacterial protein toxins have accelerated the development of toxin-based cargo-delivery vehicle platforms. This review provides an updated survey of the status of available platforms for targ

SUBMITTER: Wilson BA 

PROVIDER: S-EPMC4410985 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature