Extracellular adenosine mediates a systemic metabolic switch during immune response.

ABSTRACT: Immune defense is energetically costly, and thus an effective response requires metabolic adaptation of the organism to reallocate energy from storage, growth, and development towards the immune system. We employ the natural infection of Drosophila with a parasitoid wasp to study energy regulation during immune response. To combat the invasion, the host must produce specialized immune cells (lamellocytes) that destroy the parasitoid egg. We show that a significant portion of nutrients are allocated to differentiating lamellocytes when they would otherwise be used for development. This systemic metabolic switch is mediated by extracellular adenosine released from immune cells. The switch is crucial for an effective immune response. Preventing adenosine transport from immune cells or blockin

SUBMITTER: Bajgar A 

PROVIDER: S-EPMC4411001 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature