Ontology highlight
ABSTRACT:
SUBMITTER: Ling SC
PROVIDER: S-EPMC4411085 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Ling Shuo-Chien SC Polymenidou Magdalini M Cleveland Don W DW
Neuron 20130801 3
Breakthrough discoveries identifying common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these disorders. They share unexpectedly similar signatures, including dysregulation in common molecular players including TDP-43, FUS/TLS, ubiquilin-2, VCP, and expanded hexanucleotide repeats within the C9ORF72 gene. Dysfunction in RNA processing and protein homeostasis is an emerging theme. We present the case here that these two pro ...[more]