A Multi-Component Model of Hodgkin's Lymphoma.

ABSTRACT: Hodgkin's lymphoma is an example for a tumor with an extremely tight interaction of tumor cells with cells from the tumor micro-environment. These so-called bystander cells are not inert but interact actively with the tumor cells. Some of these cells support tumor growth by delivery of co-stimulating and anti-apoptotic signals ("helper cells"). Other cells ("killer cells") are involved in the anti-tumor immune response which is obviously not efficient enough for tumor elimination. The activity of both helper cells and killer cells is regulated by additional cells in the stroma ("regulatory cells"). The dynamic behavior of such multi-component systems is difficult to predict. In the present paper we propose a model that can be used for simulation of essential features of this system. In thi

SUBMITTER: Staege MS 

PROVIDER: S-EPMC4411114 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature