Protein expression profiles characterize distinct features of mouse cerebral cortices at different developmental stages.

ABSTRACT: The proper development of the mammalian cerebral cortex requires precise protein synthesis and accurate regulation of protein expression levels. To reveal signatures of protein expression in developing mouse cortices, we here generate proteomic profiles of cortices at embryonic and postnatal stages using tandem mass spectrometry (MS/MS). We found that protein expression profiles are mostly consistent with biological features of the developing cortex. Gene Ontology (GO) and KEGG pathway analyses demonstrate conserved molecules that maintain cortical development such as proteins involved in metabolism. GO and KEGG pathway analyses further identify differentially expressed proteins that function at specific stages, for example proteins regulating the cell cycle in the embryonic cortex, and pr

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4411115 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature