Plasmonic nanodiamonds: targeted core-shell type nanoparticles for cancer cell thermoablation.

ABSTRACT: Targeted biocompatible nanostructures with controlled plasmonic and morphological parameters are promising materials for cancer treatment based on selective thermal ablation of cells. Here, core-shell plasmonic nanodiamonds consisting of a silica-encapsulated diamond nanocrystal coated in a gold shell are designed and synthesized. The architecture of particles is analyzed and confirmed in detail using electron tomography. The particles are biocompatibilized using a PEG polymer terminated with bioorthogonally reactive alkyne groups. Azide-modified transferrin is attached to these particles, and their high colloidal stability and successful targeting to cancer cells overexpressing the transferrin receptor are demonstrated. The particles are nontoxic to the cells and they are readily internal

SUBMITTER: Rehor I 

PROVIDER: S-EPMC4411186 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature